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Linking cerebellar functional gradients to transdiagnostic behavioral dimensions of psychopathology

Highlights
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Linking cerebellar functional gradients to transdiagnostic behavioral dimensions of psychopathology.

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Associations between patterns of cerebellar connectivity gradients and behavioral measures could be represented into four latent dimensions.

Abstract
High co-morbidity and substantial overlap across psychiatric disorders encourage a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience and psychopathology. Converging evidence suggests that the cerebellum is involved in a wide range of cognitive functions and mental disorders. An important question thus centers on the extent to which cerebellar function can be linked to transdiagnostic dimensions of psychopathology. To address this question, we used a multivariate data-driven statistical technique (partial least squares) to identify latent dimensions linking human cerebellar connectome as assessed by functional MRI to a large set of clinical, cognitive, and trait measures across 198 participants, including healthy controls (n = 92) as well as patients diagnosed with attention-deficit/hyperactivity disorder (n = 35), bipolar disorder (n = 36), and schizophrenia (n = 35).
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Sehr interessant. Diese 4 latenten Dimensionen aus der Studie sind
(Link zum Bild jeweils wo auch Beschreibungen zu finden sind):

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3.2. LV1: General psychopathology LV1 Visualisierung
3.3. LV2: Impulsivity and mood LV2 Visualisierung
3.4. LV3: Internalizing and less externalizing symptoms LV3 Visualisierung
3.5. LV4: Executive dysfunction LV4 Visualisierung

Discussion:
Although the importance of cerebellar function in mental health and disease is increasingly recognized, the degree to which cerebellar connectivity is associated with transdiagnostic behavioral dimensions of psychopathology remains largely unknown. Leveraging a unique dataset including resting-state fMRI and behavioral assessments spanning clinical, cognitive, and personality traits, we found robust correlated patterns of cerebellar connectivity gradients and behavioral measures that could be represented in four transdiagnostic dimensions. Each dimension was associated with a unique spatial pattern of cerebellar connectivity gradients, and linked to different clusters of behavioral measures, supporting that individual variability in cerebellar functional connectivity can capture variability along multiple behavioral dimensions across psychiatric diagnoses. Our findings highlight the relevance of cerebellar neuroscience as a central piece for the study and classification of transdiagnostic dimensions of psychopathology.

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